Oxytocin

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Oxytocin

Post  supertucker1 on Sun Feb 05, 2012 4:01 pm

Here is some really interesting research about Oxytocin. There is a person on the yahoo ssrisex site that has reported a reinvigorated libido specifically from sublingual Oxytocin. When I visited Dr. Goldstein he actually prescribed sublingual Oxytocin pills for me as part of his "PSSD Cocktail", but I never filled the prescription because I never found a pharmacy that carried it. I have also heard that there is a cream that can be applied directly to the genitals and is supposed to increase arousal.

Btw - Buspar increases Oxytocin in the brain..................


http://www.ncbi.nlm.nih.gov/pubmed/18655889

http://www.ncbi.nlm.nih.gov/pubmed/18475254

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Re: Oxytocin

Post  Sonny on Tue Feb 07, 2012 9:26 am

Yea, I had seen that oxytocin looked promising. The only problem was that it would only last a few minutes. If we can find something that stays in your system longer, that could be a good way to treat this.

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Oxytocin

Post  supertucker1 on Tue Feb 07, 2012 11:39 pm

I'm not saying this is the cure, but here is a subjective account of one person's response to Oxytocin. It just seems like this may be worth researching a little bit more before anyone discounts it as another placebo or scam.


"""""I took Buspar for several years while I was on Prozac. I started it after being on the Prozac alone for some time and noticed a significant increase in my libido which stayed the entire time I was on it. I still had some difficulty reaching orgasm but had a very high sex drive which is unusual for someone on an SSRI (I don't think at the time I drew the correlation.) I tapered off both Buspar and Prozac over the course of 7 months. At that time both my sex drive and function disappeared 100%. That was more than 3 years ago. The genital anesthesia has improved about 40% in that time but the libido has been absent most of the time. I take a lot of supplements and some bio-identical hormones which have helped tremendously with the anxiety, anhedonia & body aches and pains but until recently didn't help my PSSD. The last week in December I had my 6 month appt. with my hormone doctor. She had recently been to a seminar where they discussed the hormone Oxytocin. Knowing about my PSSD she thought of me and asked if I would like to try it. I take a very small dose of bio-identical Oxytocin that has been compounded into a troche I put under my tongue in the morning. I didn't have very high expectations since not much of anything else seemed to work over the years. The next morning I woke up with an erotic dream. The "feelings" lasted out that day along with sexual thoughts. Since previously I'd had a few pockets of days (~2-3 days every few months) I didn't get too excited because I knew it could dissappear as fast as it came. I've been taking the Oxytocin now for 12 days and for the last 11 days I have been in fantasy heaven. Unfortunately, I still have crappy, unpleasurable orgasms, but the lead in is pretty good. Now for Buspar... I did some reading on Oxytocin. It turns out that Buspar has some impact on the Oxytocin receptors. Hum... interesting since they seem to react the same for me. I'm just hopeful this keeps up. Now, if I could only find something to help the other stuff."""""

"""""I've been doing a lot more reading on Oxytocin since I am now on day 20 of having a very active libido since starting this bio-identical form of the hormone. (This is from a zero libido 98% of the time.) I thought I'd share some of what I found since this is the first truly significant improvement I've experienced in the past three years. Still all new to me but the following research regarding both drug induced damages and sexual issues are compelling."""""




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Re: Oxytocin

Post  Sonny on Wed Feb 08, 2012 12:12 pm

Yea, that's what I meant. It sounds like the form that person took was longer lasting. I'll have to see if I can find some of that. It's probably hard to get though.

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Re: Oxytocin

Post  supertucker1 on Mon Feb 13, 2012 1:42 am

It's also possible that the Oxytocin can stimulate the sexual centers of the brain or receptors in the genitals. Could help us "re-sensitize" to sexual stimuli. Just a thought............

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Re: Oxytocin

Post  supertucker1 on Wed Mar 07, 2012 2:02 am

Here is a guide to Oxytocin. It also includes many ways to obtain it legally within the US. The guy who writes the pdf describes his own experiences with the different forms. He doesn't necessarily have an objective viewpoint, but he describes the benefits of sublingual Oxytocin as lasting several hours.



http://oxytocincentral.com/files/OxytocinGuideFinal.pdf

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Re: Oxytocin

Post  Sonny on Wed Mar 07, 2012 10:03 am

I'll check it out. It might be worth a try.

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Consistent with your theory ?

Post  amid on Sun Mar 18, 2012 10:31 pm

Hello Sonny,
I was following your postings about your theory on the effects of SSRI on the 5HT1A receptors and sexual dysfuctions resuting from that. You had also mentioned that Huperazone seemed to relieve your symptoms (along with Buspar?) in another earlier posting. Is it still the case ?

Just wanted to find out if these act in a manner consistent with theory that 5HT1A antagonists could help. Let me know your thoughts.

PS I recently tried Pramipexole and noticed a very quick drop in libido within a day, seems consistent with your theory.

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Re: Oxytocin

Post  Sonny on Mon Mar 19, 2012 9:52 am

Yes both of those help. Huperzine I take 100mg twice a day. Buspar I take 15mg 3 times a day, mainly for anxiety. Taken that way it only helps a little. It is mainly at higher doses where it can be used to get short term symptom relief. The problem with 5HT, is it's not always clear whether is presynaptic or postsynaptic. The presynaptic is desensitized and has less serotonin acting on it, which gives you more on the postsynaptic. So I think buspar in higher doses is able to increase serotonin on the presynaptic autoreceptor, without being so much that it causes the negative feedback loop which makes it go down, which in turn increases serotonin on the post synaptic. This is because it is a partial agnoist. Then in addition to lowering postsynaptic because it raised presynaptic, I think it may also compete with serotonin on the postsynaptic, causing an additional net decrease there. It's pretty complicated though, so it's hard to keep it all straight.

So anything that acts on it could be good. You can have an agonist and an antagonist with similar effects because of the receptor's inverse relationship, and a negative feedback loop on one side.

It's decrease on certain dopamine receptors is part of how it works. It's effects on oxytocin may also come into play.

So my theory is that the autoreceptor is desensitized, like the negative feedback is stuck to the "on" setting. This greatly increases serotonin on the postsynaptic side. These have a dramatic effect on various other receptors, hormones and body processes.

So the ultimate fix would be normalizing those reseptors. However by increasing a few things like dopamine, oxytocin and a couple other things, you may get everything to back to normal and just bypass the autoreceptor.

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Re: Oxytocin

Post  Sonny on Wed Mar 28, 2012 9:15 am

I got Oxytocin Factor. There isn't really any Oxytocin in it though. It is liquid breath freshener, that's it. So the company they talk about where you need a prescription is probably the only place that has any real Oxytocin. So I think if we want to raise the levels of this, it would have to be done indirectly by tweaking related receptors.

At least they refund your money if you aren't satisfied. So that's good.

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Re: Oxytocin

Post  supertucker1 on Wed Apr 11, 2012 6:01 pm

http://www.ncbi.nlm.nih.gov/pubmed/17233773

J Sex Med. 2007 Jan;4(1):14-28.
Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies.
de Jong TR, Veening JG, Olivier B, Waldinger MD.
Source

Department of Psychopharmacology, Utrecht Institute of Pharmacological Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands.
Abstract

INTRODUCTION:
Selective serotonin reuptake inhibitors (SSRIs) differ in the severity of induced ejaculation delay. Various studies indicate that oxytocin is involved in sexual behavior.

AIM:
To review and evaluate the involvement of oxytocin in SSRI-induced ejaculation delay.

MAIN OUTCOME MEASURES:
Oxytocin release, 5-hydroxytryptamine (5-HT) neurotransmission, and desensitization of 5-HT(1A) receptors.

METHODS:
A review and critical analysis of animal studies investigating the interaction of serotonergic and oxytocinergic neurotransmission in relation to the ejaculation process.

RESULTS:
Although acute treatment with the SSRIs fluoxetine and paroxetine immediately causes increased serotonin levels, delayed ejaculation does not occur. The increased serotonin levels induce oxytocin release via activation of 5-HT(1A) receptors, and this might compensate for the inhibitory actions of serotonin on sexual behavior. Chronic treatment with fluoxetine and paroxetine desensitizes 5-HT(1A) receptors on oxytocin neurons, and that might in part determine the onset of delayed ejaculation. Desensitization of 5-HT(1A) receptors is less strong following chronic treatment with the SSRIs fluvoxamine or citalopram, which may attenuate the degree of delayed ejaculation.

CONCLUSIONS:
Preliminary data suggest that the severity of chronic SSRI treatment-induced delayed ejaculation and the differences between the various SSRIs in inducing ejaculation delay is related to gradual desensitization of 5-HT(1A) receptors on oxytocin neurons.

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Re: Oxytocin

Post  supertucker1 on Wed Apr 11, 2012 6:09 pm

http://www.dailymail.co.uk/health/article-2126823/Oxytocin-Forget-Viagra-Cuddle-drug-new-way-boost-bedroom-performance.html

Very interesting article, and recent!

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Nitric Oxide Connection????

Post  supertucker1 on Fri Apr 13, 2012 4:09 am

http://findarticles.com/p/articles/mi_m0FDL/is_3_14/ai_n27448236/?tag=content;col1


Alternative treatment of fibromyalgia using the oxytocin-hormonal-nutrient protocol to increase nitric oxide

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Re: Oxytocin

Post  Sonny on Fri Apr 13, 2012 8:09 am

That all looks very promising, if I can get a hold of some. This stuff looks like just what we need, if it ever become available.
http://en.wikipedia.org/wiki/WAY-267,464


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Re: Oxytocin

Post  supertucker1 on Fri Apr 13, 2012 6:27 pm

http://www.youtube.com/watch?v=Y2mHO6QrKV0

According to this doctor, giving the body exogenous doses of Oxytocin causes the body to produce more Oxytocin.

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